Online ISSN 2149-1895
Abstract - Association Between the Immune System Response and Body Mass Index Among Hepatitis C Virus Patients
Osama H. Al-Jiffri

Background: Recently, about 2.35% of the world population, are estimated to be chronically infected with hepatitis C virus (HCV). However, the role of immune system dysfunction happening in state of obesity among HCV is poorly understood.

Objective: The purpose of this study was to determine the strength of the association between the human immune response and body mass index (BMI) and whether differences exist in the effects of obesity on selected immune parameters among HCV Saudi patients.

Subjects and Methods: Two hundred non-hypertensive, non-cirrhotic Saudi patients with chronic HCV infection; Patients were divided in to two equal groups according to their body mass index : Group (A):  Included HCV patients with a BMI more than 25 kg/m2 (the obese group). Group (B): Included HCV patients with a BMI between 18.5 and 23 kg/m2 (the normal-weight group). Parameters CD3, CD4 and CD8 were quantified. Leukocyte and differential counts were performed.  

Results: We observed elevation with regard to the normal weight group in the parameters of white blood cells, neutrophils, monocytes, CD3, CD4 and CD8 for group A . CD3 , CD4 and CD8 correlated with BMI only as a total amount, as well as with all measured parameters of blood count.

Conclusion: There is a strong association between BMI and the human immune system among HCV patients.

Volume 5, Number 4 (2015)